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Insulin products typically have short expiration dating once the container is opened. If your insulin is in a vial, it is stable for 28 days once it is opened regardless of whether it is refrigerated or not. If your insulin is in a pen form, it is stable for 10 to 28 days(depending on insulin type)unrefrigerated, and up until the manufacturer's expiration date on the box if it is refrigerated regardless if it is opened or not.