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Insulins that are packaged in a vial should be refrigerated at all times. It is stable at room temperature for only 28 days. If you do a lot of travelling, you may want to use insulin that comes in prefilled or refillable pens. These pens keep insulin stable at room temperature for 10 to 28 days, but will keep refrigerated insulin stable until the expiration date on the box-which could be up to 2 years.