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Many of the prescription heartburn medications are also available over the counter, but in lower strengths. For example, Zantac is available in 150mg and 300mg as a prescription, but only as a 75mg tablet over the counter. If you travel and forget to take your 150mg prescription with you, you can go to the drugstore and purchase the 75mg otc tablets and simply take 2 of them. Other anti-heartburn medications available as both prescription and otc are Pepcid and Tagamet.